"If we didn't make any changes, we'd be looking at spending close to a billion dollars on these medications in 2026," McHugh added
Retatrutide vs Tirzepatide vs Semaglutide Three compounds dominate current GLP-1-class research conversation: semaglutide (single agonist), tirzepatide (dual agonist), and retatrutide (triple agonist)
"So it's very challenging," Yacawych says, "to be able to separate these side effects, like nausea, from GLP-1's intended effects, like weight loss." A possible workaround came from a team led by Ernie Blevins of the University of Washington
It may also assist with prescription coordination through an external pharmacy network
Compounded versions typically come as lyophilized (freeze-dried) powder that requires reconstitution with bacteriostatic water before use