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The rationale for combining them is mechanistic complementarity (different signaling pathways, both implicated in tissue repair) and clinical anecdote in the peptide-therapy community not formal head-to-head or combination-vs-monotherapy data

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Clinical trials combining these agents reported 35-40% discontinuation rates when both were dosed together

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4% (placebo) due to adverse events Clinical Significance: This pivotal Phase 2 study established cagrilintide as an effective monotherapy for obesity, producing weight loss competitive with GLP-1 agonists but through a distinct mechanism