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PD-specific Syn variants impede chaperone-assisted protein refolding Molecular chaperones bind to the hydrophobic region of nascent, unfolded, or misfolded proteins and assist in their protein folding 61,62

Diabetes Research and Clinical Practice, 203, 110881

These studies confirmed the weight lowering efficacy of liraglutide in this setting, showing a BW change ranging from 6.0% to 5.8% with liraglutide compared to 2.0 to 1.5% with placebo 21,22

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Nevertheless, there is now a consensus suggesting that the effect of Se intake on hyperglycemia has a U-shaped doseresponse curve, i.e., a dose above the recommended level (55 micrograms/day) causes hyperglycemia (and hyperinsulinemia) [55,57]