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The situation changed dramatically when it was proposed to use NMR as a method for HDX detection (Dempsey, 2001), and NMR-based HDX detection was the leading technique in the field until the early 2000s, when mass spectrometry (MS) emerged as an extremely powerful alternative (Deng et al., 2016

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Ein niedriges Hufigkeitsprofil in anekdotischen Berichten darf deshalb nicht mit nachgewiesener Sicherheit verwechselt werden