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Glia 55 , 12631271 (2007)

Saldeen, P., & Saldeen, T

IL-2 induces and stabilizes the main transcription factors Forkhead box protein P3 (Foxp3) by activating the signal transducer and activator of transcription 5 (STAT5) pathway[23].The core of the Th17/Treg balance lies in the reciprocal antagonism between RORt and Foxp3 [24].Under conditions of conflicting cytokine signals, RORt and Foxp3 can be coexpressed in nave CD4 + T cells

Mutations in C9orf72, TDP-43, VAPB, VCP , and FUS are known to disturb these ER-mitochondria associations and signaling (Stoica et al., 2014

GSH repletion has been proposed as a therapeutic intervention