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GLP-1 is traditionally seen as an ileal brake hormone since it responds to nutrients in the ileal lumen and inhibits gastric and proximal intestinal motility, which are associated with acute appetite suppression [48, 50]

The peptide has also been found to be effective in treating wounds

In the immobilized leg, GLP-1RA induced increases in pathways associated with the proteasome and muscle remodeling, including MUSTN1, a protein involved in myogenesis and muscle regeneration after injury

In a randomized Phase 2a trial specifically examining participants with MASLD and at least 10% liver fat content, Retatrutide treatment produced dose-dependent liver fat reductions

In addition, long term effects of such a diet would have to be checked before recommending it for any application