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The different OR are widely distributed throughout the central nervous system that explains the large pharmacological responses observed following administration of opioid agonists

In a rat model of ischemic stroke, administration of the herbal compound Salvia miltiorrhiza extract modulated gut microbiota composition, reduced infarct size, and decreased markers of inflammation and oxidative stress, indicating a gut-mediated neuroprotective effect (Wu J

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Orlowski, M