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2.2.3 Regulatory role of intestinal excretion Quantitative contribution: Using C14 tracer studies, Sorensen (1965) demonstrated that a significant portion of total body uric acid turnover (1/3) is excreted via the intestine (extrarenal elimination pathway) compared to 2/3 excreted renally ( 2.2.4 Mechanisms of renal and intestinal urate reabsorption and excretion Renal and intestinal handling of urate relies on specific transporters to maintain systemic urate levels

Front Pharmacol 2022;13:974829

The addition of glutamate to folate derivatives traps the molecules in the cell and allows for accumulation in the mitochondria, a process required for the synthesis of glycine

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PMID: 26108334