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While individual responses vary, there is a physiological basis for this: different sites have different rates of absorption, and slower absorption may reduce the intensity of GI side effects
These ketone bodies (KB), including acetoacetic acid (acetoacetate), acetone and beta-hydroxybutyric acid (HB), can be utilized by the brain, heart and skeletal muscle through the citric acid cycle (Krebs cycle) and act as an energy source when glucose is not readily available (see Figure 1) (57)
GLP-1 agonists like semaglutide and tirzepatide slow gastric emptying by 30-40% as part of their mechanism of action (Nauck et al., Diabetologia, 2011)
Such research faces threats from dramatic cuts to federal research funding
95% CI, 0.82-0.92)
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