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14 -iodolactone is undetectable in human tissue in the presence of iodine deficiency but becomes detectable with iodine administration at levels 100x the RDA

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The short-lived OH radical, once formed, attacks biomolecules non-specifically in a diffusion-limited reaction, allowing it to degrade proteins, polysaccharides, and nucleic acids within just a few nanometers of its generation site (Shivakumar and Kumar 2018)