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[56] In individuals with obesity, chronic low-grade inflammation often leads to "leptin resistance"a pathological state where circulating leptin levels are high, but the brain fails to register the signal, leading to persistent hunger

While further research is needed to establish definitive causality and optimal treatment protocols, the current evidence strongly suggests these medications provide meaningful brain benefits beyond their established metabolic effects

In addition, GLP-1 also increases how full we feel after meals

Reference sources: PubChem Retatrutide | Nature Structural Basis of Triple Agonism Retatrutide vs

Maintaining weight loss in the long term could actually slow down or even reverse obesity-related issues