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Shaking creates mechanical stress and air bubbles that can break fragile amino acid chains and degrade the compound

Washington, DC, National Academy Press, pp 1-50

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VASCULAR GROWTH & BLOOD VESSEL STIMULATION The peptide BPC-157 may play a role in promoting vascular health and repairing blood vessels through: Enhanced Nitric Oxide (NO) Production It has been shown to activate endothelial nitric oxide synthase (eNOS), improving vascular function and integrity