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Ghrelin is another possible player, since it has been proven to be expressed not only in the gut, but also in a distinct subpopulation of islet cells named -cells (231) and, being known to be a stress-induced (232) GLP-1 secretagogue (233, 234), it might play an important role in the intra-islet signaling

Spann, however, said she worries that GLP-1 drugs could make the symptoms of binge eating disorder worse

Unfortunately, this was not enough to stop Lily from using them regularly and perhaps more worryingly, despite knowing they're illegal, she also admits to selling nasal sprays and promoting them on social media

The common gut symptoms are usually worst while the dose is being increased, then ease over the following weeks for most people (Moiz 2025)

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