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Several lines of evidence suggest decreased oxidative metabolism in some brain areas in SZ ( FIGURE 2 An early study by During the de novo synthesis of purine nucleotides, many reactions require a great deal of energy utilizing the hydrolysis of adenosine triphosphate (ATP)

Tilg H, Effenberger M

Quercetin can block the HMGB1/RAGE/NF-B axis to inhibit the release of pro-inflammatory factors such as TNF- and IL-6, target the NLRP3 inflammasome to block the maturation of IL-1/IL-18, and restore the balance of immune cell apoptosis by upregulating miR-204 to inhibit the HIF1/NFATc2 axis and the Src-STAT3-NFAT pathway (Rajabi et al., 2020

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Preclinical studies demonstrated that pretreatment with 2-deoxyglucose (2-DG) induced autophagy and restricted the growth of M