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SREBP1: element binding transcription factor 1

While hypogonadism is the most common change in the pituitary-gonadal axis, CPP, though rare, has been documented in children with PWS and could be linked to loss-of-function variations in the MKRN3 gene at the 15q11-q13 locus (228, 229)

This is, as he points out, a significant difference as it doesnt quite require maintaining the status quo on not launching the drug until an interim judicial determination