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It is approved by the FDA and EMA to support weight loss in people with BMI 30 kg/m 2 or 27 kg/m 2 and obesity-related co-morbidity [9, 17]

While these actions are similar to those of GLP-1 analogs like Wegovy and Zepbound, there is some evidence that, compared to GLP-1 drugs, amylin analogs are better tolerated and help preserve lean muscle mass

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Cost issues GI intolerance Availability Patient preference Practical approach No formal washout is usually required in routine practice

DPP4 inhibition improves functional outcome after renal ischemia-reperfusion injury