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While the combination of hormone replacement therapy and GLP-1 based medications shows strong early promise, much of the current evidence focuses on short-term weight outcomes rather than long-term effects on cardiovascular health, cognitive function, and overall healthspan Future research will need to be more precise

Ma S, We L, Yang H et al (2017) Emerging technologies to achieve oral delivery of GLP-1 and GLP-1 analogs for treatment of type 2 diabetes mellitus (T2DM)

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To assess the metabolic stability of the synthesized peptides, serum metabolism studies were conducted using blood obtained from 4-month-old male Sprague-Dawley rats