This degradation pathway was also linked to the virulence of the opportunistic pathogen (Breisch et al., 2022)
Notably, mitochondrial dysfunction is closely linked to NLRP3 inflammasome activationbone marrow-derived macrophages deficient in Lcn2 exhibit reduced mitochondrial damage, accompanied by diminished NLRP3 activation and decreased IL-1 production [126]
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References 1.Gregg EW, Li Y, Wang J, Rios Burrows N, Ali MK, Rolka D, et al
Its influence extends to increasing muscle mass, supporting bone density, and enhancing tissue repair, making it essential for healthy growth and development