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The ability of hydroxocobalamin to rapidly scavenge and detoxify cyanide by chelation has resulted in several acute animal and human studies using systemic hydroxocobalamin doses at suprapharmacological doses as high as 140 mg/kg to support its use as an intravenous (IV) treatment for cyanide exposure

Another small study found that overweight people who drank about 2 cups of dark roasted coffee a day lost slightly more weight during the 4-week study period than those who had the same amount of light roast coffee