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Although the fundamental mechanisms of GLP-1, GIP and GCG are outlined in the present review, the subsequent discussion primarily focuses on GLP-1RAs, since the direct oncologic evidence for GIP and GCG remains comparatively limited

In the PNA group, altered patterns of protein expression were also observed, with proteins such as CPOX and DPF2 being downregulated, while AMT and GSTM3 were upregulated (Fig

This is normal and typically resolves within 12 weeks of resuming consistent dosing

RETA reduced blood glucose from ~ 190 mg/dL to approximately 80 mg/dL after 1 week, which steadily rose after 2 weeks of treatment over the remainder of the study to ~130 mg/dL while Veh controls maintained blood glucose ~ 180 mg/dL from baseline to endpoint (Fig