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Trial populations tend to be more homogeneous than the real-world patient population

Neonatal bilirubin production-conjugation imbalance: effect of glucose-6-phosphate dehydrogenase deficiency and borderline prematurity

Still higher than tirzepatide's 6.2%

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Based on preclinical and early human data, activating all three pathways is thought to reduce appetite, improve insulin sensitivity, increase energy expenditure, and support fat breakdown effects that have shown substantial weight loss results in early-phase clinical trials, including a phase 2 study published in the New England Journal of Medicine (2023)