Retatrutide is a next-generation triple agonist (GLP-1, GIP, and GCGR) widely examined in laboratory studies focused on energy balance, metabolic regulation, and multi-pathway peptide signalling
Common side effects include nausea, vomiting, diarrhoea, and constipation consistent with the known GLP-1 receptor agonist class profile
These can cause: Heart palpitations (a rapid or irregular heartbeat) Increased blood pressure (which is especially risky if you've got an existing heart condition) Anxiety or jitters Insomnia, especially if you wear the patch late in the day Digestive or systemic issues Even though the patch bypasses the stomach, the ingredients still enter your bloodstream
Minor nerve damage is common and seen in as many as 79% of patients, but most of this resolves within six months and sometimes up to a year
Niger J Surg 2013;19:49-55.ArticlePubMed 47