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However, this model has come into question, as evidence demonstrating local, intra-islet GLP-1 production has advanced the competing hypothesis that the incretin activity of GLP-1 may reflect paracrine signaling of GLP-1 from alpha-cells on GLP-1Rs on beta-cells

Treatment algorithm proposed by the 2019 ESC guidelines on CVD, pre-DM and DM, reproduced from reference 18 with permission from Oxford University Press on behalf of the European Society of Cardiology

At the end of the study mice were euthanised with 2.5 ml/kg pentobarbitone

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