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Clinical evidence: in a cohort study involving 4,125 elderly individuals, higher cereal-derived RS intake (15 g/day) was associated with a 28% reduction in serum IL-6 levels and a 35% reduction in TNF- levels compared to low-RS intake ( 90%sufficient to meet 25% of daily protein requirements and support tryptophan (serotonin precursor) and tyrosine (dopamine precursor) supply (304)

In addition, GAMT activity was not detected in the head kidneys (a major immune organ) of HSB, and intestinal GAMT activity was high in 40-g HSB but was undetectable in 240-g HSB (Table 3) due to developmental changes in the tissue-specific expression of enzymes