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Retatrutide is Eli Lilly and Company investigational next-generation obesity drug, designed to act on three signals in the body connected to appetite, fullness, blood sugar and energy use: GLP-1, GIP and glucagon

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We previously found that fusion of a peptide or a single-chain variable fragment to the C-terminal end of albumin reduced FcRn binding up to 2-fold, and to a greater extent than when fused to the N-terminal end 12

Second Generation The second generation moved from single GLP-1 activity toward dual incretin agonism