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The FDA has reviewed Eli Lillys injectable tirzepatide products, Mounjaro and Zepbound, for safety and effectiveness

The remaining two trials, a trial with tirzepatide in people with obesity and type 2 diabetes (SURMOUNT-2) [50] and a cardiovascular outcomes trial with semaglutide (SUSTAIN 6) [31], had a duration of 72 and 104 weeks, respectively

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Carnitine Annu Rev Biochem 1988

Despite recognition of the severe medical and socioeconomic burden of obesity, the weight-loss effects of pre-existing AOMs are insufficient to overcome obesity-associated complications