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Observational studies had moderate risk of bias

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The "U-100" designation means the syringe is calibrated so that 100 units equals exactly 1 mL

IGF-1 LR3 differs from endogenous IGF-1 in one critical way: the arginine substitution at position 3 prevents binding to IGF-binding proteins (IGFBPs), extending circulation time and allowing the peptide to remain bioavailable far longer than native IGF-1