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Die Entwicklung von Danuglipron und Lotiglipron wurde aufgrund einer mglichen Lebertoxizitt abgebrochen

Recommendations for safe prescribing include (Lewis 2013): Reduce medication dosages in general (consult your healthcare professional before making a change) Opioid analgesics, anxiolytics, and sedatives can cause or worsen hepatic encephalopathy symptoms and should be used cautiously Non-steroidal anti-inflammatory drugs (NSAIDs) can more readily cause renal failure and gastrointestinal bleeding in patients with cirrhosis and should generally be avoided Anticancer and immunomodulating drugs