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Based on the evidence from multi-center long-term cardiovascular outcome trials (CVOTs) which showed that GLP-1 RAs could reduce cardiovascular mortality and the incidence of non-fatal myocardial infarction or non-fatal stroke, GLP-1 RAs have been incorporated into clinical guidelines by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) [6,7,8,9,10]

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This oxidation stress leads to skin aging, formation of wrinkles and fine lines and dull complexion