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Intercrossing Cre + and Cre Dpp4 loxP heterozygotes resulted in 4 genotypes: WT mice with no Cre recombinase, mice homozygous for LoxP sites within the Dpp4 gene ( Dpp4 fl/fl ), WT mice expressing Cre recombinase ( Tie2-Cre and Vil1-Cre ), and Dpp4 fl/fl mice expressing Cre recombinase ( Dpp4 EC/ and Dpp4 Gut/ )