Combination protocols leverage three principles
Intracellular ROS and/or RNS induced the production of protein hypersulfonic acid (P-SOH) or glutathione hypersulfonic acid (GSOH) intermediates, leading to modification
In contrast, curcumin has demonstrated coordinated inhibition of DNMTs (DNMT1, DNMT3A, DNMT3B), suppression of histone deacetylases (HDAC1, HDAC3), and modulation of non-coding RNAs and m 6 A RNA methylation within the same cellular context
This particularly applies to complex diseases, in which clinical manifestations result from intricate crosstalk among different molecular effectors [24]
Lastly, epithalon plays a significant role in the endocrine system by increasing levels of endogenous hormones that naturally diminish with age, such as melatonin (which helps regulate the sleep cycle), and gonadotropic hormones (FSG, LG, prolactin), which play a role in reproductive functions [8]