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Uncovering CNS access of lipidated exendin-4 analogues by quantitative whole-brain 3D light sheet imaging

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We noted that data were collected during different time periods (reusable, reprocessed cystoscope data were collected in 2020, and single-use, disposable cystoscope data were collected in 2021), which may introduce systematic errors in the measurement due to retrospective data collection or confounders not accounted for, such as changes in clinical practice between the 2 study years

It was first synthesized in the 1990s, based on the amino acid composition of epithalamin, a peptide extract derived from the bovine pineal gland