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Each complex is composed of several copies of three enzymes: E1, E2, and E3

High levels of copper are accumulated near Abeta peptide-containing plaque in the brain

[16] [87] [88] This includes noradrenergic neurons in the locus coeruleus, dopaminergic neurons in the ventral tegmental area, histaminergic neurons in the tuberomammillary nucleus, and serotonergic neurons in the dorsal raphe nucleus

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