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Furthermore, in hypothyroid rats without sesame oil supplementation, plasma HDL levels were lower at low thyroid status (23 pmol/L) and increased at normal thyroid status (28.5 pmol/L)

Several subsequent animal studies using different illnesses models revealed a consistent upregulation of iodothyronine deiodinase 2 (D2) both in the PVN and in tanycytes, suggesting an increase in local T 3 production, which helped explain the abnormal negative feedback resulting in TRH downregulation besides low levels of serum T 3 (65, 66)

Pan T-L, Wang P-W, Hung C-F, Aljuffali IA, Dai Y-S, Fang J-Y