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Along with that, ageing would lower the number of nephrons which consequently diminish normal kidney functions by affecting glomerular filtration rate, excess uric acid production, accumulation of creatinine in blood and loss of total kidney function [54,55]

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Pretreatment with Dula protected against AA-induced UC by decreasing colon mass index, colon weight and weight/length ratio, colonic macroscopic damage, and Dula also showed the ability to reduce oxidative stress damage via decreasing the lipid peroxidation end product, MDA, and restoring the decreased GSH, SOD, and TAC levels

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