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It is known that several cytokines, such as IL-6, IL-10, and TGF-, which activate STAT3 signaling, are potent inducers of the differentiation and activation of MDSCs [97]

The statistical testing strategy for the confirmatory secondary end points used a separate alpha spending function to control type I error rate at a 1-sided level of 2.5%, which aligned with the P value adjustment for the group sequential design

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When administered locally and intraperitoneally there were no remarkable changes in motor functioning observed by the researchers [2]