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calculated the risk to be 4.8/10,000 in groups taking GLP-1 RAs compared to 4.6/10,000 in the control groups, failing to show a statistically significant difference in aspiration or other complications between the two groups (Chang et al
In most cases, the condition is self-limited and responds to supportive care and symptomatic relief including rest, elevation if a dependent extremity is affected, and use of compression stockings
ISBN 978-0-470-12309-6
assuming IV-equivalent exposure from a subcutaneous dose is not justified by current evidence
Additional comparative evidence comes from: A 2025 narrative review synthesising randomised and indirect comparison data across obesity and type 2 diabetes trials, confirming tirzepatides superiority on weight and HbA1c [2]
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