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In addition, GLP-1 can reduce cardiomyocyte apoptosis and increases left ventricular ejection fraction through AMPK activation and NF-B downregulation
The decrease of cholesteryl esters in the modified fraction VLDL + LDL caused by L-carnitine suggests changes in fatty acid composition that favor the catabolism of this fraction 15
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In a randomised, placebo-controlled double blinded phase 1 study of ascending single doses in healthy overweight humans, cotadutide was shown to be safe and, in common with the GLP-1 analogues, to be associated with dose-dependent gastrointestinal adverse events especially nausea and vomiting
free T4 concentration is unaltered
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