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Its incidence and mortality rates vary by region ( Metabolic reprogramming, characterized by alterations in lipid, glucose, and amino acid metabolism, is a hallmark of cancer and enables malignant cells to adapt to the unique features of the tumor microenvironment (TME) ( This review summarizes recent studies on the role of ammonium metabolism in the prostate cancer microenvironment, discusses its potential as a therapeutic target, and explores its application as a diagnostic biomarker for prostate cancer to improve both detection and prognosis
