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Splitting a single weekly dose into multiple smaller injections would alter this pharmacokinetic profile, potentially creating peaks and valleys in medication concentration rather than the steady levels the medication was designed to maintain
doi: 10.1073/pnas.0712245105 19 ZhangQYaoDRaoBJianLChenYHuKet al
a patient may be responsive to a dose of between about 50 mg and 100 mg of sildenafil, but is responsive much less than 100% of the time, such as is responsive about 25% to about 50% of the time