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The kidney specific outcome was a composite of ESKD, doubling of creatinine or death from a renal cause, and was reduced by 34% in the treatment group (HR, 0.66
Harwaldt P, Rahlfs S and Becker K
Initial concerns were raised after findings from the cardiovascular outcome trial (CVOT), Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes 6 (SUSTAIN 6), revealed a greater risk of DR-related complications, defined as the need for laser therapy, intravitreal injections, development of vitreous hemorrhage, and blindness, in semaglutide users compared to placebo (3.0% vs 1.8%, HR=1.76, P =.02)
The protein guide for semaglutide includes strategies for increasing protein intake when you do not feel like eating, and protein shakes formulated for GLP-1 users can fill gaps when solid food feels unappealing
While during this time frame the percentage of new users with type 2 diabetes decreased, there was a twofold increase in the proportions of users without type 2 diabetes and a BMI of 30 kg/m 2 or greater, as well as in participants with a BMI of 27 to 30 kg/m 2 and an obesity-related comorbid condition
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