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Ethics declarations Competing interests The authors declare no competing interests

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Ozempic is approved to help manage type 2 diabetes and reduce cardiovascular risk, while Wegovy is approved to assist with weight loss and for chronic weight management (in conjunction with a reduced-calorie diet and increased physical activity) in people with obesity or who are overweight with at least one weight-related condition

In this Review, we summarize the data from CVOTs of GLP1R agonists in patients with T2DM and describe the actions of GLP1R agonists on the heart and blood vessels

Clinical trials have shown a significant weight reduction of 15 to 20 percent over 72 weeks, making tirzepatide an effective option for managing obesity when other methods fall short