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Furthermore, Verhagen et al

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In the same trial, those on oral semaglutide lost an average of 4.7 kg (approximately 10 lbs) versus 3.8 kg (approximately 8 lbs) with empagliflozin from baseline to week 52 in weight

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The mechanisms are not fully understood but may involve GLP-1 receptor distribution in the central nervous system, gastrointestinal effects, dehydration, or vascular changes