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Likewise, the ATO+MTX combination decreased tumor burden and extended the survival of NOD scid gamma (NSG) mice transplanted with patient-derived ALL xenograft, but only in one of four ALLs tested

For handling missing values, we applied the strict 20% rule (i.e., removal of variables containing more than 20% missing values) to minimize as much as possible the presence of spurious signals in our datasets, thus strengthening the power of further statistical analyses (crucial if considering the relatively small size of the study population, as a consequence of our strict inclusion criteria and further stratification according to the PO status)

GLP-1 (glucagon-like peptide-1) receptor agonists work by mimicking a natural hormone that helps regulate appetite and blood sugar

Because it has been marketed and used outside authorised medical pathways, the literature includes case reports and warnings tied to unregulated use

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