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Both sections should be updated together

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Although this is consistent and mechanistically validated across different preclinical models, as reviewed in the Preclinical and clinical applications of NAD + -modulating interventions for mitochondrial homeostasis and health benefits section, the correspondence between NAD + changes and mitochondrial or metabolic alterations is more complex in human studies

This, in turn, reduces glucose oxidation and uptake by peripheral tissues

Starting at the standard initiation dose is still recommended, but extending each escalation step to 6-8 weeks instead of 4 weeks is a common clinical adjustment