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By upregulating the mitochondrial anti-apoptotic pathway through an increase in AMP-activated protein kinase (AMPK) phosphorylation and an increase in the Bcl-2/Bax ratio (AMPK), modest dosages of withaferin A were found to have a cardioprotective effect in this rat investigation [54]

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All participants has a CD4+ T lymphocyte count greater than 100 cells/mm^3, as well as HIV-1 RNA less than 10,000 copies/mL