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These symptoms suggest that the condition involves systemic metabolic dysfunction rather than localized tissue damage

Patients should contact their provider if leg cramps are severe, persistent, or accompanied by swelling, weakness, or dark urinesymptoms suggesting rhabdomyolysis or serious muscle injury

Amelanotic melanoma appears as a pink, reddish, skin-colored, or nearly colorless spot

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Of note, we chose not use blocking steps during immunohistochemistry because, in our hands and that of others 63 , it rarely seems to improve the quality of our observations