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Metformin, known primarily for stimulating autophagy and apoptosis via the EGFR/AKT/AMPK/mTOR pathway in SCLC (92), may indirectly influence ferroptosis given the central role of the AMPK/mTOR hub in this crosstalk, although direct evidence is required

Landscapes Health & Medical Sciences (AREA) Chemical & Material Sciences (AREA) Organic Chemistry (AREA) Life Sciences & Earth Sciences (AREA) General Health & Medical Sciences (AREA) Medicinal Chemistry (AREA) Animal Behavior & Ethology (AREA) Veterinary Medicine (AREA) Public Health (AREA) Pharmacology & Pharmacy (AREA) Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA) General Chemical & Material Sciences (AREA) Chemical Kinetics & Catalysis (AREA) Bioinformatics & Cheminformatics (AREA) Engineering & Computer Science (AREA) Biochemistry (AREA) Neurosurgery (AREA) Molecular Biology (AREA) Gastroenterology & Hepatology (AREA) Genetics & Genomics (AREA) Toxicology (AREA) Proteomics, Peptides & Aminoacids (AREA) Neurology (AREA) Biomedical Technology (AREA) Biophysics (AREA) Endocrinology (AREA) Heart & Thoracic Surgery (AREA) Cardiology (AREA) Zoology (AREA) Reproductive Health (AREA) Pulmonology (AREA) Psychology (AREA) Diabetes (AREA) Hematology (AREA) Dermatology (AREA) Gynecology & Obstetrics (AREA) Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA) Medicinal Preparation (AREA) Peptides Or Proteins (AREA) Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA) Abstract The present invention discloses new pharmaceutical compositions useful for the treatment of various human and animal diseases

As master cells of the body, stem cells possess the remarkable ability to repair damaged tissues and organs