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For example, excess growth hormone causes insulin resistance and hyperglycemia, whereas IGF1 has insulin-like effects that reduce blood glucose levels and has been used experimentally to treat both type 1 and type 2 diabetes

In addition, non-pharmacological interventions for gout, including dietary modifications, weight management, and physical therapies, demonstrate multi-target efficacy by reducing serum uric acid levels, modulating inflammatory pathways, and improving metabolic parameters, thereby decreasing flare frequency, preventing complications, and complementing pharmacotherapy in mild-to-moderate cases