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doi:10.1016/j.eururo.2015.04.024

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Female gender, not having diabetes, greater baseline BW and weight loss in the first 16 weeks are potential predictors of better response to treatment 112

The systematic analysis found that cartilage lesions complicated by limited progenitor cell activity and healing capacity, large size, high mechanical demands, local and systemic inflammation, or other systemic diseases are often excluded from treatment, likely due to complications and poor outcomes after cartilage restoration procedures in this context